Supermassive Black Holes from Ultra-Strongly Self-Interacting Dark Matter

We consider the cosmological consequences if a small fraction ($f\lesssim 0.1$) of the dark matter is ultra-strongly self-interacting, with an elastic self-interaction cross-section per unit mass $\sigma\gg1\ \mathrm{cm^{2}/g}$. This possibility evades all current constraints that assume that the self-interacting component makes up the majority of the dark matter. Nevertheless, even a small fraction of ultra-strongly self-interacting dark matter (uSIDM) can have observable consequences on astrophysical scales. In particular, the uSIDM subcomponent can undergo gravothermal collapse and form seed black holes in the center of a halo. These seed black holes, which form within several hundred halo interaction times, contain a few percent of the total uSIDM mass in the halo. For reasonable values of $\sigma f$, these black holes can form at high enough redshifts to grow to $\sim10^9 M_\odot$ quasars by $z \gtrsim 6$, alleviating tension within the standard $\Lambda$CDM cosmology. The ubiquitous formation of central black holes in halos could also create cores in dwarf galaxies by ejecting matter during binary black hole mergers, potentially resolving the "too big to fail" problem.Comment: submitted to Ap

Jean Epstein

Filmmaker and theoretician Jean Epstein profoundly influenced film practice, criticism and reception in France during the 1920s and well beyond. His work not only forms the crux of the debates of his time, but also remains key to understanding later developments in film practice and theory. Epstein' s film criticism is among the most wide-ranging, provocative and poetic writing about cinema and his often breathtaking films offer insights into cinema and the experience of modernity. This collection - the first comprehensive study in English of Epstein's far-reaching influence - arrives as several of the concerns most central to Epstein' s work are being reexamined, including theories of perception, realism, and the relationship between cinema and other arts. The volume also includes new translations from every major theoretical work Epstein published, presenting the widest possible historical and contextual range of Epstein' s work, from his beginnings as a biology student and literary critic to his late film projects and posthumously published writings.Filmmaker en -theoreticus Jean Epstein beïnvloedde sterk de filmpraktijk, -kritiek en -receptie in Frankrijk en ver daarbuiten tijdens de jaren twintig van de vorige eeuw. Zijn werk vormde niet alleen de kern van de debatten in die tijd, maar is ook een sleutel voor het begrijpen van latere ontwikkelingen in de filmpraktijk en -theorie. Epsteins filmkritieken zijn uiteenlopende, uitdagende en poëtisch geschreven teksten, en zijn vaak adembenemende films bieden belangrijke en moderne inzichten in de cinema. Dit boek verschijnt op het moment dat een aantal van de thema' s die centraal staan in het werk van Epstein opnieuw wordt onderzocht, met inbegrip van de theorie van de waarneming, realisme en de relatie tussen cinema en de andere kunsten. De kritische essays vormen een waardevolle inleiding tot het creatieve oeuvre van Epstein

Jean Epstein

Filmmaker and theoretician Jean Epstein profoundly influenced film practice, criticism and reception in France during the 1920s and well beyond. His work not only forms the crux of the debates of his time, but also remains key to understanding later developments in film practice and theory. Epstein' s film criticism is among the most wide-ranging, provocative and poetic writing about cinema and his often breathtaking films offer insights into cinema and the experience of modernity. This collection - the first comprehensive study in English of Epstein's far-reaching influence - arrives as several of the concerns most central to Epstein' s work are being reexamined, including theories of perception, realism, and the relationship between cinema and other arts. The volume also includes new translations from every major theoretical work Epstein published, presenting the widest possible historical and contextual range of Epstein' s work, from his beginnings as a biology student and literary critic to his late film projects and posthumously published writings

Feasibility of Fluoroscopy-Free Endovascular Navigation in Subjects of Different Ages

https://digitalcommons.unmc.edu/emet_posters/1013/thumbnail.jp

Proteomic profiling of urinary proteins in renal cancer by surface enhanced laser desorption ionisation (SELDI) and neural-network analysis: Identification of key issues affecting potential clinical utility.

Recent advances in proteomic profiling technologies, such as surface enhanced laser desorption ionization mass spectrometry, have allowed preliminary profiling and identification of tumor markers in biological fluids in several cancer types and establishment of clinically useful diagnostic computational models. There are currently no routinely used circulating tumor markers for renal cancer, which is often detected incidentally and is frequently advanced at the time of presentation with over half of patients having local or distant tumor spread. We have investigated the clinical utility of surface enhanced laser desorption ionization profiling of urine samples in conjunction with neural-network analysis to either detect renal cancer or to identify proteins of potential use as markers, using samples from a total of 218 individuals, and examined critical technical factors affecting the potential utility of this approach. Samples from patients before undergoing nephrectomy for clear cell renal cell carcinoma (RCC; n 48), normal volunteers (n 38), and outpatients attending with benign diseases of the urogenital tract (n 20) were used to successfully train neural-network models based on either presence/absence of peaks or peak intensity values, resulting in sensitivity and specificity values of 98.3–100%. Using an initial “blind” group of samples from 12 patients with RCC, 11 healthy controls, and 9 patients with benign diseases to test the models, sensitivities and specificities of 81.8–83.3% were achieved. The robustness of the approach was subsequently evaluated with a group of 80 samples analyzed “blind” 10 months later, (36 patients with RCC, 31 healthy volunteers, and 13 patients with benign urological conditions). However, sensitivities and specificities declined markedly, ranging from 41.0% to 76.6%. Possible contributing factors including sample stability, changing laser performance, and chip variability were examined, which may be important for the long-term robustness of such approaches, and this study highlights the need for rigorous evaluation of such factors in future studies

Acute effect of repeated sprints on inter-limb asymmetries during unilateral jumping

The aim of the present study was to investigate the effects of multiple repeated sprints on unilateral jump performance and inter-limb asymmetries. Eighteen recreationally active males performed three single leg countermovement jumps (SLCMJ) as baseline data. The repeated sprint protocol was 6 x 40 m with 20 seconds of passive rest between each sprint. This protocol was conducted four times, each set separated by four minutes of rest. Within that rest period, subjects performed one SLCMJ on each limb after two minutes of rest. A one-way ANOVA showed significant reductions (p < 0.05; ES = -0.52 to -0.99) in jump height on both limbs after each set relative to baseline. Inter-limb asymmetries increased at each time point and ranged from 7.62-14.67%, with significant increases in asymmetry seen after sets three (p = 0.046) and four (p = 0.002). Significant increases in sprint time were shown between sprints one and six in each set (p ≤ 0.01). A fatigue index (%) was also calculated and showed an exponential increase from 5.74% (set one) to 13.50% (set four), with significant differences between all sets (p < 0.001) with the exception of sets three and four. Results from this study show that a 6 x 40 m repeated sprint protocol is a sufficient dose for implementing acute fatigue in recreationally active subjects. This was manifested by reductions in jump height at all time points and jump height asymmetries after the third and fourth sets. These findings indicate that jump height from unilateral jump testing may be a useful metric to use during the monitoring process in recreationally trained athletes

Mechanism of action of VP1-001 in cryAB(R120G)-associated and age-related cataracts

PurposeWe previously identified an oxysterol, VP1-001 (also known as compound 29), that partially restores the transparency of lenses with cataracts. To understand the mechanism of VP1-001, we tested the ability of its enantiomer, ent-VP1-001, to bind and stabilize αB-crystallin (cryAB) in vitro and to produce a similar therapeutic effect in cryAB(R120G) mutant and aged wild-type mice with cataracts. VP1-001 and ent-VP1-001 have identical physicochemical properties. These experiments are designed to critically evaluate whether stereoselective binding to cryAB is required for activity.MethodsWe compared the binding of VP1-001 and ent-VP1-001 to cryAB using in silico docking, differential scanning fluorimetry (DSF), and microscale thermophoresis (MST). Compounds were delivered by six topical administrations to mouse eyes over 2 weeks, and the effects on cataracts and lens refractive measures in vivo were examined. Additionally, lens epithelial and fiber cell morphologies were assessed via transmission electron microscopy.ResultsDocking studies suggested greater binding of VP1-001 into a deep groove in the cryAB dimer compared with ent-VP1-001. Consistent with this prediction, DSF and MST experiments showed that VP1-001 bound cryAB, whereas ent-VP1-001 did not. Accordingly, topical treatment of lenses with ent-VP1-001 had no effect, whereas VP1-001 produced a statistically significant improvement in lens clarity and favorable changes in lens morphology.ConclusionsThe ability of VP1-001 to bind native cryAB dimers is important for its ability to reverse lens opacity in mouse models of cataracts

Noise kernel for a quantum field in Schwarzschild spacetime under the Gaussian approximation

A method is given to compute an approximation to the noise kernel, defined as the symmetrized connected 2-point function of the stress tensor, for the conformally invariant scalar field in any spacetime conformal to an ultra-static spacetime for the case in which the field is in a thermal state at an arbitrary temperature. The most useful applications of the method are flat space where the approximation is exact and Schwarzschild spacetime where the approximation is better than it is in most other spacetimes. The two points are assumed to be separated in a timelike or spacelike direction. The method involves the use of a Gaussian approximation which is of the same type as that used by Page to compute an approximate form of the stress tensor for this field in Schwarzschild spacetime. All components of the noise kernel have been computed exactly for hot flat space and one component is explicitly displayed. Several components have also been computed for Schwarzschild spacetime and again one component is explicitly displayed.Comment: 34 pages, no figures. Substantial revisions in Secs. I, IV, and V; minor revisions elsewhere; new results include computation of the exact noise kernel for hot flat space and an approximate computation of the noise kernel for a thermal state at an arbitrary temperature in Schwarzschild spacetime when the points are split in the time directio

In situ longitudinal pre-stretch in the human femoropopliteal artery

In situ longitudinal (axial) pre-stretch (LPS) plays a fundamental role in the mechanics of the femoropopliteal artery (FPA). It conserves energy during pulsation and prevents buckling of the artery during limb movement. We investigated how LPS is affected by demographics and risk factors, and how these patient characteristics associate with the structural and physiologic features of the FPA. LPS was measured in n = 148 fresh human FPAs (14–80 years old). Mechanical properties were characterized with biaxial extension and histopathological characteristics were quantified with Verhoeff–Van Gieson Staining. Constitutive modeling was used to calculate physiological stresses and stretches which were then analyzed in the context of demographics, risk factors and structural characteristics. Age had the strongest negative effect (r = −0.812, p \u3c 0.01) on LPS and could alone explain 66% of LPS variability. Male gender, higher body mass index, hypertension, diabetes, coronary artery disease, dyslipidemia and tobacco use had negative effects on LPS, but only the effect of tobacco was not associated with aging. FPAs with less pre-stretch had thicker medial layers, but thinner intramural elastic fibers with less dense and more fragmented external elastic laminae. Elastin degradation was associated with decreased physiological tethering force and longitudinal stress, while circumferential stress remained constant. FPA wall pathology was negatively associated with LPS (r = −0.553, p \u3c 0.01), but the effect was due primarily to aging. LPS in the FPA may serve as an energy reserve for adaptive remodeling. Reduction of LPS due to degradation and fragmentation of intramural longitudinal elastin during aging can be accelerated in tobacco users